{"id":4687,"date":"2025-02-03T12:32:55","date_gmt":"2025-02-03T11:32:55","guid":{"rendered":"https:\/\/cnatm-1.betapage.de\/?page_id=4687"},"modified":"2025-06-27T08:48:30","modified_gmt":"2025-06-27T06:48:30","slug":"projekte","status":"publish","type":"page","link":"https:\/\/cnatm.de\/en\/projekte\/","title":{"rendered":"Projects"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"4687\" class=\"elementor elementor-4687\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-962f83c p-clean-h-v14-1  elementor-section-full_width elementor-section-content-middle elementor-section-height-default elementor-section-height-default\" data-id=\"962f83c\" data-element_type=\"section\" data-e-type=\"section\" id=\"p-clean-h-v14-1\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4e043a2a outer-col\" data-id=\"4e043a2a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6051b477 inn elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6051b477\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3b865b6 col21 animated-slow\" data-id=\"3b865b6\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;,&quot;animation_delay&quot;:0,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-582ea8e elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"582ea8e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Our research projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3545f82 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3545f82\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cae7d9e\" data-id=\"cae7d9e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c6e3584 animated-slow elementor-widget elementor-widget-heading\" data-id=\"c6e3584\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><br>Nucleic acid-based agents for difficult-to-treat diseases<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e87a6dc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e87a6dc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c15e062\" data-id=\"c15e062\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc8f3d6 elementor-widget elementor-widget-text-editor\" data-id=\"dc8f3d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In CNATM, we are moving away from traditional protein-centred drug development and developing nucleic acids as therapeutics. Nucleic acids are the most promising class of molecules to achieve rapid development of highly specific therapeutics - as already demonstrated by the mRNA-based COVID-19 vaccines. We are exploiting an even broader spectrum that includes chemically modified mono- and dinucleotides, oligonucleotides such as siRNAs or antimirs as well as aptamers. Infections, inflammations, tumours and cardiovascular diseases cause around 75% of all deaths in the EU. Available therapies are often ineffective or limited to symptom relief, so there is a significant medical need.<\/p><p>We aim to take active ingredients from development through validation to preclinical testing within a few years.  Our 14 industrial partners are closely involved in the projects from the very beginning and make a significant contribution through research activities, syntheses and drug formulations.<\/p><p>Our cluster is divided into 4 collaborative projects. In collaborative projects 1-3, we are working on our research and development projects around 3 major overarching themes in 11 work packages. In our centrally coordinated joint project 4 we work on our innovation support measures.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-203a8a2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"203a8a2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0cc5c16\" data-id=\"0cc5c16\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ce781ee elementor-widget elementor-widget-spacer\" data-id=\"ce781ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1882f6 elementor-widget elementor-widget-ha-creative-button happy-addon ha-creative-button\" data-id=\"e1882f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-creative-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-magnetic=\"no\" class=\"ha-creative-btn-wrap\">\n\t\t\t<a class=\"ha-creative-btn ha-stl--hermosa ha-eft--reshape\" href=\"https:\/\/cnatm.de\/en\/innovationen\/\" rel=\"nofollow\"><span>Our innovation support measures<\/span><\/a>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fffe66e elementor-widget elementor-widget-spacer\" data-id=\"fffe66e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e214afc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e214afc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-327f6d9\" data-id=\"327f6d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-097971c elementor-widget elementor-widget-heading\" data-id=\"097971c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Mono- and dinucleotides<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0cd3491 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0cd3491\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-952eadb\" data-id=\"952eadb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b5dbbf elementor-widget elementor-widget-spacer\" data-id=\"1b5dbbf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9f170e elementor-widget elementor-widget-ha-post-list happy-addon ha-post-list\" data-id=\"d9f170e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-post-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"ha-post-list-wrapper\">\n\t\t\t\t<ul class=\"ha-post-list\" >\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/decitabin-analoga-fuer-die-therapie-der-akuten-myeloischen-leukaemie\/\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP1-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Decitabin Analoga f\u00fcr die Therapie der akuten myeloischen Leuk\u00e4mie\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP1-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP1-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Decitabine analogues for the therapy of acute myeloid leukemia<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Decitabine analogues for the therapy of acute myeloid leukemia: Decitabine is a synthetic nucleoside that can significantly slow the progression of acute myeloid leukaemia (AML) through an epigenetic<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/cgamp-analoga-fuer-die-immunvermittelte-tumortherapie\/\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP2-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"cGAMP Analoga f\u00fcr die immunvermittelte Tumortherapie\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP2-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP2-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">cGAMP analogs for immune-mediated tumor therapy<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>cGAMP analogs for immune-mediated tumor therapy: Stimulator of Interferon Genes (STING) is a receptor that plays a significant role in inflammatory and degenerative diseases.<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-be538c2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"be538c2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b569e52\" data-id=\"b569e52\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ed47ad7 elementor-widget elementor-widget-spacer\" data-id=\"ed47ad7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26c87a2 elementor-widget elementor-widget-heading\" data-id=\"26c87a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Oligonucleotides and their targeted delivery<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1fd8e20 elementor-widget elementor-widget-spacer\" data-id=\"1fd8e20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ae5fd9b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ae5fd9b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9666a14\" data-id=\"9666a14\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-343a647 elementor-widget elementor-widget-ha-post-list happy-addon ha-post-list\" data-id=\"343a647\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-post-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"ha-post-list-wrapper\">\n\t\t\t\t<ul class=\"ha-post-list\" >\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/chemische-modifikation-von-sirnas-fuer-optimiertes-delivery-in-zellen\/\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP3-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Chemische Modifikation von siRNAs f\u00fcr optimiertes Delivery in Zellen\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP3-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP3-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Chemical modification of siRNAs for optimized delivery into target cells<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Chemical modification of siRNAs for optimized delivery into target cells: While mRNA vaccines were important in the containment of the COVID-19 pandemic, no antivirals with<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/library-und-machine-learning-unterstuetze-evolution-von-nanopartikeln\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP4-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Library- und Machine-Learning unterst\u00fctze Evolution von Nanopartikeln\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP4-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP4-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Library and machine learning assisted evolution of nanoparticles<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Library and machine learning assisted evolution of nanoparticles: One of the key challenges for nucleic acid therapeutics is their delivery into cells. The embedding of nucleic acids in liposomal nanoparticles is often chosen<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/microrna-basierte-therapie-der-copd\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP6-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"microRNA-basierte Therapie der COPD\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP6-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP6-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">microRNA-based therapy of COPD<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>microRNA-based therapy of COPD: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Currently, there is no therapy that can interfere with the underlying inflammatory processes of COPD.<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/ncrna-targeting-in-tumoren-und-entzuendung\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP7-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"ncRNA-Targeting in Tumoren und Entz\u00fcndung\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP7-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP7-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">ncRNA targeting in tumors and inflammation<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>ncRNA targeting in tumors and inflammation: WP7 focuses on the observation that macrophages may have a significant role in the development of certain tumors<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/peptid-gekoppelte-antisense-oligonukleotide-als-neue-klasse-von-antibiotika\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP11-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Peptid-gekoppelte Antisense-Oligonukleotide als neue Klasse von Antibiotika\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP11-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP11-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Peptide-coupled antisense oligonucleotides as a new class of antibiotics<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Peptide-coupled antisense oligonucleotides as a new class of antibiotics: The widespread use of classical antibiotics carries the risk of multi-resistance and also leads to unwanted side effects such as<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db78811 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"db78811\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b7cef4\" data-id=\"8b7cef4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3c98f98 elementor-widget elementor-widget-spacer\" data-id=\"3c98f98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bc219d elementor-widget elementor-widget-heading\" data-id=\"9bc219d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">mRNA agents and other principles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5f299c elementor-widget elementor-widget-spacer\" data-id=\"a5f299c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0eac0ed elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0eac0ed\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0f67295\" data-id=\"0f67295\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-43063ec elementor-widget elementor-widget-ha-post-list happy-addon ha-post-list\" data-id=\"43063ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-post-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"ha-post-list-wrapper\">\n\t\t\t\t<ul class=\"ha-post-list\" >\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/evolution-von-mrna-vakzinen\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP5-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Evolution von mRNA-Vakzinen\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP5-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP5-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Evolution of mRNA vaccines<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Evolution of mRNA vaccines: The replacement of uridine by 1-methylpseudouridine helped mRNA vaccines against COVID-19 to achieve significantly improved pharmacological properties. However, the limited shelf life and laborious formulation<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/aptamere-gegen-kardiovaskulaere-erkrankungen\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP8-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Aptamere gegen kardiovaskul\u00e4re Erkrankungen\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP8-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP8-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Aptamers against cardiovascular diseases<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Aptamers against cardiovascular diseases: WP8 addresses two significant and often fatal cardiovascular diseases: Carotid artery stenoses and aneurysms of the abdominal aorta. In both cases, changes in<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/gen-editierung-bei-duchenne-muskeldystrophie\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP9-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"Gen-Editierung bei Duchenne-Muskeldystrophie\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP9-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP9-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">Gene editing in Duchenne muscular dystrophy<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Gene editing in Duchenne muscular dystrophy: WP9 is dedicated to cardiovascular diseases, in this case in the context of skeletal muscle disease. Specific guide RNAs for CRISPR\/Cas-based gene therapy of DMD will be developed<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"ha-post-list-item\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/cnatm.de\/en\/mrna-basierte-therapie-der-hepatitis-b\/\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP10-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-post-image\" alt=\"mRNA-basierte Therapie der Hepatitis B\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP10-150x150.png 150w, https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP10-500x500.png 500w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t<div class=\"ha-post-list-content\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"ha-post-list-title\">mRNA-based therapy of hepatitis B<\/h2>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ha-post-list-excerpt\">\n\t\t\t\t\t\t\t\t\t\t\t<p>mRNA-based therapy of hepatitis B: Hepatitis B is a very common chronic viral disease that is difficult to cure. The established therapy is based on the use of<\/p>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Unsere Forschungsprojekte Nukleins\u00e4ure-basierte Wirkstoffe f\u00fcr schwer therapierbare Krankheiten Bei CNATM verlassen wir die traditionelle proteinzentrierte Wirkstoffentwicklung und entwickeln Nukleins\u00e4uren als Therapeutika. Nukleins\u00e4uren sind die vielversprechendste Molek\u00fclklasse, um eine schnelle Entwicklung hochspezifisch wirksamer Therapeutika zu erreichen \u2013 dies zeigten bereits die mRNA-basierten COVID-19-Vakzine. Wir sch\u00f6pfen ein noch breiteres Spektrum aus, das chemisch modifizierte Mono- und Dinukleotide, [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4687","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Projekte - CNATM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnatm.de\/en\/projekte\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projekte - CNATM\" \/>\n<meta property=\"og:description\" content=\"Unsere Forschungsprojekte Nukleins\u00e4ure-basierte Wirkstoffe f\u00fcr schwer therapierbare Krankheiten Bei CNATM verlassen wir die traditionelle proteinzentrierte Wirkstoffentwicklung und entwickeln Nukleins\u00e4uren als Therapeutika. Nukleins\u00e4uren sind die vielversprechendste Molek\u00fclklasse, um eine schnelle Entwicklung hochspezifisch wirksamer Therapeutika zu erreichen \u2013 dies zeigten bereits die mRNA-basierten COVID-19-Vakzine. 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