{"id":5556,"date":"2025-02-03T09:19:22","date_gmt":"2025-02-03T08:19:22","guid":{"rendered":"https:\/\/cnatm-1.betapage.de\/?p=5556"},"modified":"2025-02-03T09:21:44","modified_gmt":"2025-02-03T08:21:44","slug":"ncrna-targeting-in-tumoren-und-entzuendung","status":"publish","type":"post","link":"https:\/\/cnatm.de\/en\/ncrna-targeting-in-tumoren-und-entzuendung\/","title":{"rendered":"ncRNA targeting in tumors and inflammation"},"content":{"rendered":"
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ncRNA targeting in tumors and inflammation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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WP7 focuses on the observation that macrophages may have a significant role in the development of certain tumors, thus linking them to inflammatory processes. There is increasing evidence that long non-coding RNAs (lncRNAs) control essential functions of macrophages and thus have therapeutic potential. Building on a CRISPR-Cas-based screening of thousands of lncRNAs established by AG Rad, suitable targets will be identified and eventually antisense oligonucleotides against these lncRNAs will be developed.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Head: Roland Rad
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PIs:<\/strong> Roland Rad, Stefan Engelhardt, Annalisa Marsico, Gunther Meister, Michael Sattler<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\u00a0Industrial partner<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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ncRNA-Targeting in Tumoren und Entz\u00fcndung Im Fokus des WP7 steht die Beobachtung, dass Makrophagen eine bedeutende Rolle bei der Entstehung bestimmter Tumore haben k\u00f6nnen und somit eine Verbindung zu Entz\u00fcndungsprozessen besteht. Die Hinweise mehren sich, dass lange nicht-kodierende RNAs (lncRNAs) wesentliche Funktionen der Makrophagen steuern und somit therapeutisches Potential haben. Aufbauend auf einem von der […]<\/p>\n","protected":false},"author":11,"featured_media":5557,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[74],"tags":[],"class_list":["post-5556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oligonukleotide-und-ihr-gezieltes-delivery"],"acf":[],"yoast_head":"\nncRNA-Targeting in Tumoren und Entz\u00fcndung - CNATM<\/title>\n<meta name=\"description\" content=\"Im Fokus des WP7 steht die Beobachtung, dass Makrophagen eine bedeutende Rolle bei der Entstehung bestimmter Tumore haben k\u00f6nnen und somit eine Verbindung zu Entz\u00fcndungsprozessen besteht.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnatm.de\/en\/ncrna-targeting-in-tumoren-und-entzuendung\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ncRNA-Targeting in Tumoren und Entz\u00fcndung - CNATM\" \/>\n<meta property=\"og:description\" content=\"Im Fokus des WP7 steht die Beobachtung, dass Makrophagen eine bedeutende Rolle bei der Entstehung bestimmter Tumore haben k\u00f6nnen und somit eine Verbindung zu Entz\u00fcndungsprozessen besteht.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cnatm.de\/en\/ncrna-targeting-in-tumoren-und-entzuendung\/\" \/>\n<meta property=\"og:site_name\" content=\"CNATM\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-03T08:19:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-03T08:21:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cnatm.de\/wp-content\/uploads\/2025\/02\/WP7.png\" \/>\n\t<meta property=\"og:image:width\" content=\"921\" \/>\n\t<meta property=\"og:image:height\" content=\"660\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Patrizia Torelli\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Patrizia Torelli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cnatm.de\\\/ncrna-targeting-in-tumoren-und-entzuendung\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cnatm.de\\\/ncrna-targeting-in-tumoren-und-entzuendung\\\/\"},\"author\":{\"name\":\"Patrizia Torelli\",\"@id\":\"https:\\\/\\\/cnatm.de\\\/#\\\/schema\\\/person\\\/f2fc8eccad93916c1b891b5fef1ac19e\"},\"headline\":\"ncRNA-Targeting in Tumoren und Entz\u00fcndung\",\"datePublished\":\"2025-02-03T08:19:22+00:00\",\"dateModified\":\"2025-02-03T08:21:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/cnatm.de\\\/ncrna-targeting-in-tumoren-und-entzuendung\\\/\"},\"wordCount\":99,\"publisher\":{\"@id\":\"https:\\\/\\\/cnatm.de\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/cnatm.de\\\/ncrna-targeting-in-tumoren-und-entzuendung\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cnatm.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/WP7.png\",\"articleSection\":[\"Oligonukleotide und ihr gezieltes Delivery\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cnatm.de\\\/ncrna-targeting-in-tumoren-und-entzuendung\\\/\",\"url\":\"https:\\\/\\\/cnatm.de\\\/ncrna-targeting-in-tumoren-und-entzuendung\\\/\",\"name\":\"ncRNA-Targeting in Tumoren und Entz\u00fcndung - 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