{"id":5569,"date":"2025-02-03T09:54:48","date_gmt":"2025-02-03T08:54:48","guid":{"rendered":"https:\/\/cnatm-1.betapage.de\/?p=5569"},"modified":"2025-02-03T09:56:05","modified_gmt":"2025-02-03T08:56:05","slug":"chemische-modifikation-von-sirnas-fuer-optimiertes-delivery-in-zellen","status":"publish","type":"post","link":"https:\/\/cnatm.de\/en\/chemische-modifikation-von-sirnas-fuer-optimiertes-delivery-in-zellen\/","title":{"rendered":"Chemical modification of siRNAs for optimized delivery into target cells"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"5569\" class=\"elementor elementor-5569\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6363f8b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6363f8b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-807a88d\" data-id=\"807a88d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b60e27 elementor-widget elementor-widget-heading\" data-id=\"0b60e27\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Chemical modification of siRNAs for optimized delivery into target cells<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-39021d3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39021d3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c861fc\" data-id=\"3c861fc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-553a889 elementor-widget elementor-widget-spacer\" data-id=\"553a889\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39a4d74 elementor-widget elementor-widget-text-editor\" data-id=\"39a4d74\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>While mRNA vaccines were important in the containment of the COVID-19 pandemic, no antivirals with sufficient efficacy are available against SARS-CoV2. The development of synthetic small interfering RNAs (siRNAs) against virally encoded RNAs has shown initial success, but currently no clinically approved siRNAs with antiviral efficacy are available. WP3 therefore aims to develop chemically modified siRNA conjugates and siRNA formulations with enhanced target specificity. We expect that the results of this WP will result in new approaches for siRNA-based therapy of other viral infections.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-72d739a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"72d739a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-89f255c\" data-id=\"89f255c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-89a1439 elementor-widget elementor-widget-text-editor\" data-id=\"89a1439\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Head: Olivia Merkel<br \/><\/strong><\/p><p><strong>PIs:<\/strong> Olivia Merkel, Thomas Carell, Oliver Keppler, Sabine Schneider, Philip Tinnefeld<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4e4729f\" data-id=\"4e4729f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4022c7e elementor-widget elementor-widget-text-editor\" data-id=\"4022c7e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u00a0Industrial partner<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5a0182 elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"a5a0182\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;1&quot;,&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;effect&quot;:&quot;slide&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Image Carousel\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper swiper-image-stretch\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 3\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2024\/09\/Eurofins_Genomics_GmbH-768x230.png\" alt=\"Eurofins Genomics GmbH\" \/><\/figure><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 3\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2024\/09\/Nanotemper_GmbH-768x230.png\" alt=\"Nanotemper GmbH\" \/><\/figure><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"3 of 3\"><figure class=\"swiper-slide-inner\"><img decoding=\"async\" class=\"swiper-slide-image\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2024\/09\/Sitools_GmbH-768x230.png\" alt=\"Sitools GmbH\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Chemische Modifikation von siRNAs f\u00fcr optimiertes Delivery in Zellen W\u00e4hrend mRNA-Impfstoffe bei der Eind\u00e4mmung der COVID-19-Pandemie eine wichtige Rolle spielten, sind keine antiviralen Mittel mit ausreichender Wirksamkeit gegen SARS-CoV2 verf\u00fcgbar. Die Entwicklung synthetischer kleiner interferierender RNAs (siRNAs) gegen viral kodierte RNAs hat erste Erfolge gezeigt, aber derzeit gibt es keine klinisch zugelassenen siRNAs mit antiviraler [&hellip;]<\/p>","protected":false},"author":11,"featured_media":5570,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[74],"tags":[],"class_list":["post-5569","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oligonukleotide-und-ihr-gezieltes-delivery"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chemische Modifikation von siRNAs f\u00fcr optimiertes Delivery in Zellen - CNATM<\/title>\n<meta name=\"description\" content=\"W\u00e4hrend mRNA-Impfstoffe bei der Eind\u00e4mmung der COVID-19-Pandemie eine wichtige Rolle spielten, sind keine antiviralen Mittel mit ausreichender Wirksamkeit gegen SARS-CoV2 verf\u00fcgbar.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnatm.de\/en\/chemische-modifikation-von-sirnas-fuer-optimiertes-delivery-in-zellen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chemische Modifikation von siRNAs f\u00fcr optimiertes Delivery in Zellen - 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