{"id":6515,"date":"2025-02-01T14:39:01","date_gmt":"2025-02-01T13:39:01","guid":{"rendered":"https:\/\/cnatm.de\/?p=6515"},"modified":"2026-09-10T14:41:21","modified_gmt":"2026-09-10T12:41:21","slug":"cnatm-lecture-muthiah-manoharan","status":"publish","type":"post","link":"https:\/\/cnatm.de\/en\/cnatm-lecture-muthiah-manoharan\/","title":{"rendered":"CNATM-Lecture: Muthiah Manoharan"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"6515\" class=\"elementor elementor-6515\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6363f8b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6363f8b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-807a88d\" data-id=\"807a88d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b60e27 elementor-widget elementor-widget-heading\" data-id=\"0b60e27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">CNATM-Lecture: Muthiah Manoharan<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2402be3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2402be3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c4581f4\" data-id=\"c4581f4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c789369 elementor-widget elementor-widget-text-editor\" data-id=\"c789369\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>19 July 2023<\/strong><\/p><p><strong>Living in the World of RNA Therapeutics<\/strong><\/p><p>Synthetic small interfering RNAs (siRNAs) are potent inhibitors of gene expression. These molecules are perfect examples of biomimetic chemistry as synthetic siRNAs act through the natural RNA interference (RNAi) pathway. To deliver therapeutic siRNAs into\u00a0human liver, Manoharan and his team developed approaches that include chemical modification of the siRNAs and either lipid nanoparticle (LNP) formulation or multivalent N-acetylgalactosamine (GalNAc) conjugation, making possible intravenous and subcutaneous administration, respectively. This\u00a0 presentation will cover the molecular basis of RNA therapeutics and their delivery including the chemical modifications and motifs used in each RNA strand to ensure uptake into cells of the targeted tissue, Ago2 recognition, silencing efficiency, metabolic stability, and safety.<\/p><p><strong>Muthiah Manoharan<\/strong>\u00a0ist Senior Vice President of Drug Discovery bei Alnylam Pharmaceuticals, Cambridge.<\/p><p>Location: ICEM\/ House L, Seminar Room, W\u00fcrmtalstr. 201, 81377 Munich, Germany<\/p><p><strong>Registration is required for participation:<br \/><\/strong><a href=\"https:\/\/www.cas.uni-muenchen.de\/veranstaltungen\/einzelvortraege\/ev_manoharan\/index.html\">Link to registration<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d33096d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d33096d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-35ba973\" data-id=\"35ba973\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9f642c9 elementor-widget elementor-widget-image\" data-id=\"9f642c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"1083\" src=\"https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan-768x1083.png\" class=\"attachment-medium_large size-medium_large wp-image-1610\" alt=\"\" srcset=\"https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan-768x1083.png 768w, https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan-213x300.png 213w, https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan-726x1024.png 726w, https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan-1089x1536.png 1089w, https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan-1453x2048.png 1453w, https:\/\/cnatm.de\/wp-content\/uploads\/2023\/07\/cnatm_vortrag_manoharan.png 1966w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-597dc69 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"597dc69\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d07c590\" data-id=\"d07c590\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-77a75b2 elementor-widget elementor-widget-spacer\" data-id=\"77a75b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Thomas Carell h\u00e4lt Vortrag beim Novo Nordisk Symposium &#8222;Frontiers in Biophysics and Chemical Biology&#8220;<\/p>","protected":false},"author":11,"featured_media":1610,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[64],"tags":[],"class_list":["post-6515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-event"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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