Publikationen
Hier finden Sie die neuesten Publikationen aus unserem Forschungscluster. Wir laden Sie ein, sich anhand der Artikel über die neuesten Entwicklungen aus unseren Forschungsbereichen zu informieren.
2025
Novel Tet3 enzymes for next generation epigenetic sequencing
Simisir, Ö, Walter, T, Sahin, H, Carell, T, Schneider, S.
RCS Chem Biol. 2025 doi: 10.1039/D4CB00315B
STING activation improves T-cell-engaging immunotherapy for acute myeloid leukemia
A. Linder, D. Nixdorf, N. Kuhl, I. Piseddu, T. T. Xu, A. V. Holtermann, G. Kuut, R. E. Endres, N. Philipp, V. L Bücklein, J. de Graaff, T. Carell, S. Kobold, R. Kischel, V. Hornung, M. Subklewe
Blood 2025 doi: 10.1182/blood.2024026934
Design and characterization of a micro RNA-200c detecting Broccoli fluorescent light-up aptamer
Kersten, C., Zahler, S., Schneider, S.
ChemBioChem 2025, doi: 10.1002/cbic.202400772
2024
Synthesis and validation of clickable multimeric mannose ligands for dendritic cell targeting
L. Montiel, F. Spada, S. Bessinovo, A. Crisp, C. Berger, S. Wiedemann, T. Carell, T. Frischmuth
J. Carbohyd. Chem., 2024, doi: 10.1080/07328303.2024.2418524
A Phosphotriester-Masked Dideoxy-cGAMP Derivative as a Cell-Permeable STING Agonist
D. Özdemir, A. Pappa, S. Veth, S. Stazzoni, M. Müller, V. Hornung, T. Carell
Angew. Chem. Int. Ed. 2024, doi: 10.1002/anie.202416353
Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
Montero JJ, Trozzo R, Sugden M, Öllinger R, Belka A, Zhigalova E, Waetzig P, Engleitner T, Schmidt-Supprian M, Saur D, Rad R.
Nat Methods. 2024 Apr;21(4):584-596.
Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 based Gene editing at ultra-low dose
Germer J, Lessl AL, Pöhmerer J, Grau M, Weidinger E, Höhn M, Yazdi M, Cappelluti MA, Lombardo A, Lächelt U, Wagner E.
J Control Release. 2024 Jun;370:239-255. doi: 10.1016/j.jconrel.2024.04.037. Epub 2024 Apr 27.
In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting
Yazdi M, Pöhmerer J, Hasanzadeh Kafshgari M, Seidl J, Grau M, Höhn M, Vetter V, Hoch CC, Wollenberg B, Multhoff G, Bashiri Dezfouli A, Wagner E.
Small. 2024 Oct;20(42):e2400643. doi: 10.1002/smll.202400643. Epub 2024 Jun 25.
Dual Effect by Chemical Electron Transfer Enhanced siRNA Lipid Nanoparticles: Reactive Oxygen Species-Triggered Tumor Cell Killing Aggravated by Nrf2 Gene Silencing
Zhang F, Burghardt T, Höhn M, Wagner E.
Pharmaceutics. 2024 Jun 7;16(6):779. doi: 10.3390/pharmaceutics16060779.
Modulating efficacy and cytotoxicity of lipoamino fatty acid nucleic acid carriers using disulfide or hydrophobic spacers
Steffens RC, Thalmayr S, Weidinger E, Seidl J, Folda P, Höhn M, Wagner E.
Nanoscale. 2024 Jul 25;16(29):13988-14005. doi: 10.1039/d4nr01357c.
New insights for the development of efficient DNA vaccines
Berger S, Zeyn Y, Wagner E, Bros M.
Microb Biotechnol. 2024 Nov;17(11):e70053. doi: 10.1111/1751-7915.70053.
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids
Grau M, Wagner E.
Curr Opin Chem Biol. 2024 Aug;81:102506. doi: 10.1016/j.cbpa.2024.102506. Epub 2024 Aug 2.
Dual pH-responsive CRISPR/Cas9 ribonucleoprotein xenopeptide complexes for genome editing
Luo X, Germer J, Burghardt T, Grau M, Lin Y, Höhn M, Lächelt U, Wagner E.
Eur J Pharm Sci. 2024. doi: 10.1016/j.ejps.2024.106983. Epub 2024 Dec 7.
A comparative analysis of peptide-delivered antisense antibiotics using diverse nucleotide mimics
Ghosh, C., Popella, L., Dhamodharan, V., Jung, J., Dietzsch, J., Barquist, L., Höbartner, C., & Vogel, J.
(2024) RNA (New York, N.Y.), 30(6), 624–643. https://doi.org/10.1261/rna.079969.124
TCRGenesis: Generation of SIINFEKL-specific T-cell receptor sequences using autoregressive Transformer
Yang An, Felix Drost, Adrian Straub, Annalisa Marsico, Dirk H Busch, Benjamin Schubert.
OpenReview.net, Published: 13 Oct 2024
Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives
Maegdefessel L, Boon RA, Dimmeler S.
Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):3-6.
Efficient tandem Cu-catalyzed Click synthesis of multi-sugar-modified oligonucleotides
Tölke A.J., Gaisbauer J.F., Gärtner Y.V., Steigenberger B., Holovan A., Streshnev F., Schneider S., Müller M., Carell T.
Angew. Chem. Int. Ed. Engl. 2024, e202405161. doi: 10.1002/anie.202405161.
Kinetic Referencing Allows Identification of Epigenetic Cytosine Modifications by Single-Molecule Hybridization Kinetics and Superresolution DNA-PAINT Microscopy
Bauer, J.; Reichl, A.; Tinnefeld, P.
ACS nano 2024, 18, 1496–1503.
DNA Origami Vesicle Sensors with Triggered Single-Molecule Cargo Transfer
Büber, E.; Yaadav, R.; Schröder, T.; Franquelim, H. G.; Tinnefeld, P.
Angew. Chem. Int. Ed. Engl. 2024, e202408295.
Controlled mechanochemical coupling of anti-junctions in DNA origami arrays
Cole, F.; Pfeiffer, M.; Wang, D.; Schröder, T.; Ke, Y.; Tinnefeld, P.
Nat Commun 2024, 15, 7894.
Design of Experiments Grants Mechanistic Insights into the Synthesis of Spermine-Containing PBAE Copolymers
Kromer APE, Sieber-Schäfer F, Farfan JB, and Merkel OM
ACS Applied Materials & Interfaces 2024 16 (29), 37545-37554; DOI: 10.1021/acsami.4c06079
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation
M. Bérouti, K. Lammens, M. Heiss, L. Hansbauer, S. Bauernfried, J. Stöckl, F. Pinci, I. Piseddu, W. Greulich, M. Wang, C. Jung, T. Fröhlich, T. Carell, K.P. Hopfner, V. Hornung
Immunity 2024, 10.1016/j.immuni.2024.04.010
Gradual evolution of a homo-L-peptide world on homo-D-configured RNA and DNA
E. Węgrzyn, I. Mejdrova, T. Carell
Chem. Sci. 2024, 10.1039/d4sc03384a
Generation of densely labeled oligonucleotides for the detection of small genomic elements
C. Steinek, M. Guirao-Ortiz, G. Stumberger, A.J. Tölke, D. Hörl, T. Carell, H. Harz, H. Leonhardt
Cells Rep. Methods 2024, 10.1016/j.crmeth.2024.100840
Step-by-Step Towards Biological Homochirality – from Prebiotic Randomness To Perfect Asymmetry
I. Mejdrova, E. Węgrzyn, T. Carell
Chem. – Asian J. 2024, 10.1002/asia.202401074
Robust Bisulfite-Free Single-Molecule Real-Time Sequencing of Methyldeoxycytidine Based on a Novel hpTet3 Enzyme,
H. Sahin, R. Salehi, S. Islam, M. Müller, P. Giehr, T. Carell
Angew. Chem. Int. Ed. 2024, 10.1002/anie.202418500
Endo-bind-n-seq: identifying RNA motifs of RNA binding proteins isolated from endogenous sources
Tiana Nicole Hanelt, Nora Treiber, Thomas Treiber, Gerhard Lehmann, Norbert Eichner, Tamara Rothmeier, Georg Schmid, Robert Reichelt, Federico Zambelli, Giulio Pavesi, Dina Grohmann, Gunter Meister.
Life Sci Alliance. 2024;8(2):e202402782. Published 2024 Dec 2.
X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes
Tim P. Hasenbein, Sarah Hoelzl, Zachary D. Smith, Chiara Gerhardinger, Marion O. C. Gonner, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia R. V. Dragano, Patricia da Silva-Buttkus, Lillian Garrett, Sabine M. Hölter, Markus Kraiger, Manuela A. Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Nadine Spielmann, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Daniel Andergassen.
Nature Communications volume 15, Article number: 10631 (2024)
Efficient Tandem Cu-Catalyzed Click Synthesis of Multi-Sugar-Modified Oligonucleotides
Annika J. Tölke, Julia F. Gaisbauer, Yasmin V. Gärtner, Babara Steigenberger, Anna Holovan, Filip Streshnev, Sabine Schneider, Markus Müller, Thomas Carell.
Angew. Chem. Int. Ed. Engl. 2024, e202405161, doi: 10.1002/anie.202405161
Link to publication
Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity
Franziska Haase, Jana Pöhmerer, Mina Yazdi, Melina Grau, Yanira Zeyn, Ulrich Wilk, Tobias Burghardt, Miriam Höhn, Christoph Hieber, Matthias Bros, Ernst Wagner , Simone Berger.
Eur. J. Pharm. Biopharm. 2024, 95-109, doi: 10.1016/j.ejpb.2023.11.025.
Link to publication
2023
An Aminoisoxazole-Based Proto-RNA
Felix Xu, Stefan Wiedemann, Jonas Feldmann, Sidney Becker and Thomas Carell.
Chem. Europe, 2023, e202300057, doi: 10.1002/ceur.202300057
Link to publication
Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage
Christina Beck, Deepak Ramanujam, Paula Vaccarello, Florenc Widenmeyer, Martin Feuerherd, Cho-Chin Cheng, Anton Bomhard, Tatiana Abikeeva, Julia Schädler, Jan-Peter Sperhake, Matthias Graw, Seyer Safi, Hans Hoffmann, Claudia A. Staab-Weijnitz, Roland Rad, Ulrike Protzer, Thomas Frischmuth, Stefan Engelhardt.
Nat. Commun. 2023, 14, 4564. doi: 10.1038/s41467-023-40185-1
Link to publication