WP7 focuses on the observation that macrophages may have a significant role in the development of certain tumors, thus linking them to inflammatory processes. There is increasing evidence that long non-coding RNAs (lncRNAs) control essential functions of macrophages and thus have therapeutic potential. Building on a CRISPR-Cas-based screening of thousands of lncRNAs established by AG Rad, suitable targets will be identified and eventually antisense oligonucleotides against these lncRNAs will be developed.