30. November 2023, 17:15

Gene Silencing in HSPCs with an Apolipoprotein A1-Based Nanodelivery Platform

Nucleic acid therapeutics are revolutionizing healthcare via gene inhibition, addition, replacement or editing. Lipid nanoparticle (LNP) technology is the current gold standard platform that enabled the clinical translation of the first siRNA drug Onpattro and the COVID-19 mRNA vaccines. Nevertheless, current LNP systems are mostly suited for vaccine purposes following local administration or hepatic delivery following intravenous administration. To unleash RNA’s full therapeutic potential, Roy van der Meel introduces modular nanoplatform technology for systemic nucleic acid delivery to immune cells in hematopoietic organs using apolipoproteins.

Roy van der Meel is Professor of Precision Medicine in the Department of Biomedical Engineering at Eindhoven University of Technology. ist Professor für Präzisionsmedizin in der Abteilung für Biomedizinische Technik an der Technischen Universität Eindhoven.

Location: ICEM / House L, Seminarraum, Würmtalstr. 201, 81377 Munich

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