Stimulator of Interferon Genes (STING) is a receptor that plays a significant role in inflammatory and degenerative diseases. Its natural ligand is cyclic guanosine adenosine monophosphate (cGAMP), which is produced by cGAMP synthase in response to DNA mutations. The goal of this WP is to develop synthetic cGAMP analogs that act antagonistically on STING and are suitable for oral therapy of AML.